Glucagon was discovered in 1923 as a contaminant of early insulin preparations, and its
hormonal status was not established until its structure was established in the 1950 s and
when the first radioimmunoassay was developed by Roger Unger, providing information
about its secretion. Its role in hepatic glucose production was soon established and it was
proposed as an essential factor in diabetic hyperglycemia. However, even today a number
of issues remain unsolved. For instance, the assays for glucagon are not straightforward …